Thèse Nouvelles Approches Théoriques pour Séparer les Phénomènes de Repliement et d'Interaction dans le Cadre d'Une Interaction Protéine - Métal par Rmn et Apprentissage Profond H/F - 69

Établissement : Université Claude Bernard Lyon 1
École doctorale : Chimie de Lyon
Laboratoire de recherche : ISA - Institut des sciences analytiques
Direction de la thèse : Olivier WALKER ORCID 0000000172842555
Début de la thèse : 2026-10-01
Date limite de candidature : 2026-04-30T23:59:59

résumé en anglais uniquement

The work will be hosted by the Institute of Analytical Sciences (ISA) located in Lyon/Villeurbanne (France). ISA comprises around 200 researchers, recent facilities, and is among the largest analytical science centers in Europe. Cutting edge instruments are available like High field NMR spectrometers (From 600 to 1000MHz). ISA also has a very active and welcoming PhD students'association, ISATOPE. The thesis project will be developed within the Biophysics of Complex Systems (Biosys) research group. Biosys is a dynamic, multidisciplinary group gathering specialists from complementary fields towards the common goal of understanding the structural dynamics of biomedically important proteins. The thesis project will benefit from the multidisciplinary expertise of group members in protein NMR, Molecular Dynamics simulations, and machine learning. We have in-house GPU servers for MD and machine learning, along with access to French national supercomputing resources. We are seeking a motivated candidate with scientific curiosity, programming skills, and the desire to pursue interdisciplinary research. The successful candidate should have completed (or be in stage of completion) an M.Sc. degree in bioinformatics, physical chemistry or related fields. Familiarity with MD simulations, machine learning, and/or NMR would be strongly appreciated. We note that the candidate will be tasked with computational developments and analyses (programming, modelling) and will not be primarily in charge of experimental data collection (unless they express an interest for it).